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Submitted: 27 January 2014 Modified: 10 May 2014

Herdin Record #: NCR-RITM-14012707513497

Prophylactic platelets in dengue: survey responses highlight lack of an evidence base

Researchers

NameRole
1James Whitehorn Author
2Rosemari R. Roche Author
3Wilmar V. Guzman Author
4Leonard Nainggolan Author
5Ida Laksono Author
6Lucy Lum Author
7Ajay Mishra Author
8Abul Faiz Author

Publication Information

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
Public Library of Science Neglected Tropical Diseases
Frequency:
Annual
Publication Date:
2012
Volume:
6
Issue:
6
Page(s):
0
Publisher:
Public Library of Science

Abstract

Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage. As a result of this prophylactic platelet transfusions are sometimes advocated for the prevention of haemorrhage. There is currently no evidence to support this practice, and platelet transfusions are costly and sometimes harmful. We conducted a global survey to assess the different approaches to the use of platelets in dengue. Respondents were all physicians involved with the treatment of patients with dengue. Respondents were asked that their answers reflected what they would do if they were the treating physician. We received responses from 306 physicians from 20 different countries. The heterogeneity of the responses highlights the variation in clinical practice and lack of an evidence base in this area and underscores the importance of prospective clinical trials to address this key question in the clinical management of patients with dengue.


Physical Location

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext pdf