Dengue an acute mosquito-borne viral illness of sudden onset that usually follows a benign course with headache, fever, prostration, severe joint and muscle pain,swollen glands andrash. The objectives of the study are to pinpoint the changes in weather, particularly the temperature, and its relevant relationship on the occurrence of the dengue cases in Cagayan de Oro City. The significance of the study is to have some predictions on the rise of dengue cases and to be able to prevent the increase of the cases. The study will focus on theoccurrence of dengue from the year 2008 to 2010 particularly in the area of Cagayan de Oro City and relatively find a relationship on the effects of climate change on the rise of cases of dengue in the said area and for the future references. Data that were gathered was taken from the City Health Office and at Philippine atmospheric geophysical and astronomical services administration (PAG-ASA). We were able to gather a monthly data of the said years. The data gathered from PAG-ASAwas the amount of rainfalls, the mean temperature of the atmospheric temperature in Cagayan de Oro City, and the number of rainy days. The data gathered on the City Heath Office was about the monthly report of the dengue cases of the health centre of Cagayan de Oro City.